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Home > Research Department  > Health Concerns Articles > Cervical Dysplasia
    Health Concerns Articles  
CERVICAL DYSPLASIA
Articles by a Naturopathic Doctor ( N.D.)

CERVICAL DYSPLASIA

Don't skip your pap tests! cervical dysplasia may show no signs or symptoms.
There are virtually no signs and symptoms of cervical dysplasia, making a yearly PAP test vitally important for all sexually active women. It may be the only way you know you have this very common sexually transmitted disease...

It takes approximately 10 years for cervical dysplasia to develop into cancer, still one of the most common cancer deaths in women. A yearly PAP test is the most important prevention strategy and a woman has. Cervical dysplasia is treatable if caught early and in its initial non-invasive stage.

Not all cervical dysplasias will develop into cervical cancer, however squamous cell cervical cancer is almost always preceded by cervical dysplasia. Similarly, although not all Human Papillomavirus virus (HPV), a sexually transmitted infection, become cancer or even cause dysplasia, virtually all of cervical cancers and dysplasias, when present, are caused by HPV. In other words, cervical dysplasia is a sexually transmitted disease.

At puberty, the cells lining our cervix, change from columnar cells, which line the rest of the uterus, to squamous cells. This is a very normal process called metaplasia. This junction of the two type of cells is called the squamo-columnar junction, and it is here that the cells are most susceptible to another abnormal premalignant transformation (dysplasia). The bottom layer of the squamous cells is called the basal layer, where the most immature, largest cells with the biggest nuclei exist. The thickness of the basal layer determines the severity of the dysplasia (mild – severe dysplasia). In the case of Carcinoma "in situ", the immature basal cells extend all the way to the very top of the tissue thickness. As the severity of the dysplasia increases, so does the risk for cancer.

HPV has a number of subtypes that vary in terms of aggressiveness and risk of developing dysplasia. HPV 16 and 18 are considered to be the most aggressive, accounting for the largest percentage of cervical cancer cases. Besides HPV, other risks for cervical dysplasia include prior Chlamydia or HIV infection, obesity, birth before the age of 22, cigarette smoking, multiple sexual partners, poor nutrition, low socioeconomic status, family history of cervical cancer, and one proposed risk is the use of oral contraceptive medication. It has been suggested that, given some of risk factors for cervical dysplasia, an impaired or weakened immune system may play a role in its development. That being said, when our immune system is functioning at its optimum capacity, it has the power to fight even the most severe forms of dysplasia and spontaneous regression is common.

Atypia is a common PAP smear result that is misunderstood by many women. A diagnosis of Atypia is made when the cells have not changed enough to be labelled as abnormal (or dysplasia), but are not quite normal, either. Atypia, as mentioned earlier, commonly regresses on it own. This type of cell is often seen when the tissue is already in the process of repairing itself. For others, it can be a very early abnormal change and as such, should always be monitored.

There are a variety of nutritional habits and supplements that can be used to prevent HPV or treat cervical dysplasia to prevent the development of cervical cancer. Diets high in anti-oxidant rich fruits and vegetables can significantly reduce the persistence of the HPV virus. Tomatoes, yellow and orange fruits and vegetables, eggs, dark green leafy vegetables and papaya are all great sources of these nutrients. As cervical dysplasias can be an estrogen dominant concern, consuming cruciferous vegetables such as broccoli, cabbage, brussel sprouts and kale, all high in Indole-3-carbinol, are useful in prevention of cancer of cervical cancer. This has been shown to help to ensure that estrogen metabolism is being altered in such a way as to reduce the carcinogenic metabolites.

If you are find g it difficult to eat as many fruits and vegetables as you may wish, or to boost your daily anti-oxidant intake, you may decide to take a supplement such as mixed carotenoids, Vitamin A, E and C. Similarly, Indole-3-carbinol can be purchased in a supplement form. A vitamin B12 and folic acid deficiency may lead to high levels of homocysteine, which has been associated with increased risk of cervical cancer. Supplementation either orally or through intramuscular injection can increase these levels. Green tea extract as an oral treatment or topically via an ointment has shown very promising results in terms of cervical dysplasia treatment.

In terms of lifestyle goals to treat and prevent cervical dysplasia, a goal to quit smoking should be at the top of your list. Smoker are 2-3 times more likely to develop dysplasia than non-smokers. Again, stress plays a significant role in disease development and immune function. Use stress reducing techniques and exercises everyday to more effectively deal with stress. Young women should also be counselled about sex and the increased risk that unprotected sex, as well as sex with multiple partners at an early age can have on the development of HPV. Last but not least, there is evidence suggesting that long term contraceptive use can predispose women to developing a rare variant of squamous cell carcinoma called adenocarcinoma. Women on oral contraceptives should be aware that long term use (of 12 years or more) may have negative impact on overall health.

The recently developed HPV vaccine has been shown to effectively decrease the incidence of HPV. One must always keep in mind that HPV does not always lead to cervical dysplasia and the vaccine is not aimed at preventing cervical dysplasia or cancer, only the precursor of HPV.

The following list of supplements can be used for treating and preventing Cervical Dysplasia.  Adult doses are given.  (CLICK SUPPLEMENT NAME FOR PRODUCTS).

SUPPLEMENT DOSAGE THERAPEUTIC EFFECT
VITAMIN C 2-6 g/day For immune system support. Studies show low plasma levels of Vitamin C in cervical dysplasia.
MIXED CAROTENOIDS 75,000 -150,000 IU/day Beta carotene deficiency in the cervical cells plays a role in the development of cervical dysplasia.
FOLIC ACID 2.5-10 mg/day Studies have shown that women on oral contraceptives taking folic acid supplementation saw a regression of dysplasia, other studies also show a preventative effect.
VITAMIN B12 1000 mcg/day Protective against cervical dysplasia
GREEN TEA EXTRACT 300 mg/day orally. Can also be used in suppository form – insert twice weekly. Effective in the treatment of cervical dysplasia.
INDOLE-3-CARBINOL   Prevents abnormal cell growth and tumour progression in estrogen related cancers.
CURCUMIN 350-1000 mg/day Preventative of cervical cancer, down regulates the HPV virus.
VITAMIN A Vitamin A suppositories nightly for a week, followed by a week of herbal suppository (such as goldenseal or Echinacea or a combo). Continue rotating for 3 months. Use under the guidance of your health care practitioner. Used as an effective treatment of mild-moderate cervical dysplasia.
For informational purposes only.  Please consult your health care practitioner before taking natural health care products. Click here for full disclaimer.


All articles copyright National Nutrition 2008-Present.  For educational purposes only.  Please note that while National Nutrition supports your right to use natural health care products for any therapeutic purpose that you see fit, that the information on this website should not be considered as a claim or as a substitute for medical advice.

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