Isoleucine
Updated Mar. 01st, 2022
The amino acids that the body cannot produce, and need to be taken in through the diet, are called essential. Isoleucine is one of these amino acids. Isoleucine is also a member of the branched chain amino acid (BCAA) group, along with leucine and valine. BCAAs act as a fuel source for the muscle because they are the only amino acids that are broken down directly in muscle tissue. They prevent the muscle breakdown that normally occurs during strenuous exercise, resulting in increased endurance and muscle strength.
Other tissues that the BCAAs help to repair are the bones and skin. BCAAs regulate blood sugar by producing glycogen, the storage form of sugar in muscle tissue. Deficiency of isoleucine has been implicated in many health problems and causes symptoms that mimic hypoglycemia. Isoleucine also increases energy by making hemoglobin, the oxygen carrying part of the red blood cell. Isoleucine, and the other BCAAs, can be supplemented for: building muscle, healing tissue and bones, increasing energy, anemia and blood sugar imbalances.
The biologically active form of isoleucine is L-isoleucine. Branched chain supplements are the safest way to use isoleucine. They are available in a variety of ratios. The optimal ratio for normal use is 2:1:1 (leucine : isoleucine : valine). BCAA supplements should be taken a half an hour before workouts.
The branched chain amino acids must be taken together. High doses of BCAA can cause hypoglycemia and diabetics and individuals with hypoglycemia should use BCAAs with caution.