Firstly, SAMe donates molecules, called methyl groups, to other substances as a way to stabilize the molecules and reduce damage to body tissues. Methylation also forms genetic material, components of the cell membrane, the insulating coating on nerve fibers and brain chemicals.  Secondly SAMe  helps to form sulphur-containing amino acids like glutathione.

Glutathione is used by the liver to detoxify harmful chemicals.  Lastly SAMe plays a role ion the formation of polyamines.  Polyamines are molecules that regulate gene expression.  Thus they keep our cell’s growing and replicating at the proper rate.  SAMe is recommended by natural health practitioners for a variety of conditions including depression, rheumatoid and osteoarthritis, fibromyalgia, cardiovascular damage due to homocysteine, liver toxicity, liver disease, age-related disease, cognitive disorders and insomnia.

SAMe supplements are found in capsules.  It should always be taken on an empty stomach because the presence of other amino acids, from protein, will decrease the amount that is absorbed.

Side effects of SAMe include gastrointestinal upset, dry mouth and restlessness.  It should not be combined with other antidepressants, tryptophan, 5-HTP or St. Johns wort.  SAMe should not be used by individuals with bipolar disorder.  It should not be used with blood thinners or by people who have active bleeding or blood disorders.  Discontinue SAMe 2 weeks prior to surgery or dental work.