In studies, OPCs are shown to be far more powerful than antioxidants like vitamins E and C.  Additionally they work with the primary antioxidant in the liver, glutathione and recycle vitamin C so it can continue to fight free radicals.  OPCs are easily taken in by the body and even cross the blood brain barrier to provide protection to our brain and nerves.  OPCs are used for cardiovascular health because they strengthen the collagen lining of vessels, thus increasing circulation, and decreasing inflammation and blood clots.  OPCs have anti-aging properties because they protect the body from environmental pollutants, keep tissues, like the skin, elastic and keep the immune system in good working order (to prevent cancer form-
ation). Finally, OPCs stop the release of histamine thus reducing inflammation and allergic symptoms like runny nose, congestion and watery eyes.

OPC supplements are made from two sources, grape seed (Vitis vinifera) and pine bark.  The cardiovascular benefits of drinking red wine are due in part to the antioxidants from OPCs.  Grape seed extract can be purchased as a powdered beverage or encapsulated extract.  Grape seed supplements should be standardized as an assurance of the amount of OPCs they contain.  Pine bark extract is found as encapsulated extract.  It should also be standardized as an assurance of the amount of OPCs it contains.  Pycnogenol is a trademarked name for pine bark extract.

Grape seed and pine bark should not be used with blood thinners or NSAIDs, by individuals with blood disorders or a decreased ability to clot.  Grape seed and pine bark should be discontinued 2 weeks prior to surgery or dental work.  Do not use grape seed or pine bark concurrently with xanthine oxidase inhibitors or methotrexate.