- 200mg
- Indole-3-Carbinol (I3C)
microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.
Format
Veggie Caps
60 Vcaps
Dosage
Take one capsule one to two times daily with or without food, or as directed by a qualified health care practitioner.
Important Information
Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.
See Below For Cautions
- Provides antioxidant support
- Helpful for estrogen metabolism
- May help reduce the risks of abnormal cell growth
- A good choice for women to help prevent disease
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Indole-3-carbinol, or I3C, is a phytonutrient found in Brassica vegetables- relatives of the mustard plant, like broccoli, cabbage, and Brussles sprouts. For years, we've known that people who eat the most Brassica vegetables are less likely to develop many different kinds of unhealthy cells. In the last decade, evidence has been quietly accumulating to suggest that I3C (and substances made in the body from I3C, like diindolylmethane (DIM [see I3C vs DIM: Myths and Facts", below] is one of the key active immune boosting ingredients in these food (along with sulforaphane and D-Glucarate). This evidence has suggested that I3C might have potent powers to prevent- and perhaps even to treat- the killers women fear most.
"Estrogen" is actually not one substance, but a family of hormones that stimulate the growth and development of women's reproductive systems. And in fact, the effect of estrogens on the risk of many women's issues is as much a product of which estrogens and estrogen metabolites a woman is exposed to, as it is of how much estrogen her body makes.
The estrogen metabolite 16 alpha-hydroxyestrone (16OHE) is a "bad" estrogen: it can powerfully promote the development of unhealthy breast cells. On the other hand, "good" estrogens also exist, in the form of 2-hydroxyestrone (2OHE), along with 2-methoxyestradiol. These estrogen metabolites are either harmless, or may actually be protective against women's unhealthy cells.
Enter I3C
This is where I3C comes into the picture. Following up on extensive animals experimentation, the intriguing finding of several human studies has been that, by shifting the balance of metabolic enzymes that process estrogens in the body, I3C reduces the formation of "bad" estrogens, and increases the formation of "good" ones. .
Knowing the role of "bad" estrogen in the progression of harmful cervical cell growth, and I3C's ability to change estradiol metabolism from "bad" to "good," a series of experiments have been run to see how I3C might reduce the risks.
Since I3C is known to decrease the production of "bad" estrogen and to increase the production of the "good" 2OHE, you'd expect that it might have potent effects against unhealthy breast cells. In animal studies, I3C has been repeatedly shown to prevent the development of unhealthy breast cells, whether these cells occurs because of exposure to chemical carcinogens or spontaneously.
Cautions:
Consult a health care practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance, if you are taking any medications or natural health products, if you are attempting to conceive, if you have a liver disorder, or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations). Discontinue use and consult a health care practitioner if you develop liver-related symptoms (e.g., abdominal pain, jaundice) or symptoms of low estrogen. Do not use if you are pregnant or breastfeeding.
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