NAC SUSTAINED.
500MG TIMED RELEASE N-ACETYL-CYSTEINE FROM AOR. NAC Sustained is n-acetylcysteine,
the most effective enhancer of the all-important antioxidant glutathione (GSH).
NAC Sustained is delivered in an advanced, time-released technology to
maximize its effects over 8 hours. These effects include relief from the
symptoms of chronic bronchitis, heavy metal chelation and the quenching of
free radicals. [VCAPS]
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N-Acetyl-L-Cysteine |
600mg |
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Non-medicinal
ingredients: food glaze, organic sucrose, povidone,
talc. Capsule: |
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hypromellose, sorbitol,
silicon dioxide, water. |
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 60 Vcaps |
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No ingredients not
listed on the label have been added to the product. Contains no
wheat, gluten, corn, nuts, dairy, soy, eggs, fish, or shellfish. |
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Relief from the symptoms of chronic bronchitis.
Heavy metal chelation.
Antioxidant.
Precursor to glutathione.
Anti-mucus in the lungs.
Acetaminophen overdose.
Immune responses.
AIDS complications.
Anti-HIV activity in-vitro.
Liver detoxification.
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Take one capsule twice daily with/without food, or as
directed by a qualified health practitioner. |
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AOR
Clinical dosage and therapeutic
specialty supplements recommended by practitioners for their purity,
potency, and effectiveness.
> view
other products from AOR
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WHAT NAC SUSTAINED IS AND WHO CAN BENEFIT FROM IT
N-Acetyl-L-Cysteine, or NAC, is an amino acid that acts as an antioxidant
and is a precursor to glutathione (GSH). While glutathione can be described
as the most important endogenously produced antioxidant in the human body,
it is also a (tri)peptide, and the body has a tendency to cleave peptides
into their individual units. In the case of glutathione, those individual
amino acid units are glutamic acid, glycine and cysteine. Of these, cysteine
is the most critical for GSH synthesis, and N-acetyl-l-cysteine is an
excellent form of cysteine. Therefore, while there is still a school of
thought that believes supplemental glutathione can be effective, the fact
remains that the most important component for the synthesis of glutathione
is NAC. NAC is also more bioavailable than glutathione and is approximately
6 times as cost-effective. However, it is in the role of glutathione
precursor that NAC exerts most of its beneficial effects. These include
clinical applications for:
1. Heart disease. NAC has the unique ability to inhibit
levels of a specific lipoprotein called Lp(a), which is a highly advanced
indicator of heart disease. In fact, Lp(a) is a much more reliable indicator
than blood cholesterol levels, low density lipoprotein (HDL) levels, or the
ratio of LDL to HDL.
Diets and drugs designed to lower blood cholesterol levels do not lower Lp(a)
levels. Recently, it was reported that NAC is the most effective nutrient
known to lower Lp(a) levels. In fact, NAC is capable of lowering Lp(a)
levels by 70%. LP(a) is comprised of an LDL particle attached to the large
glycoprotein apo(a) by one or more disulfide bonds. NAC breaks up the
disulfide bonds by converting each disulfide group into two sulphydryl
groups.
NAC also inhibits heart damage by preventing LDL from being oxidized, by
reducing plasma homocysteine levels, and by free-radical quenching effects.
NAC also protects against ischaemic and reperfusion damage. NAC also
potentiates the coronary dilating and anti-platelet effects of
nitroglycerine as well as limiting the development of tolerance to
nitroglycerine. Finally, ST-depression, a clinical sign of myocardial
ischemia, was not seen following pretreatment with NAC, suggesting
attenuation of impaired tissue oxygenation and preservation of myocardial
performance by NAC.
2. Immunity and AIDS. NAC affects immunity via its role in
intracellular GSH production. This role becomes critical when normal GSH
production pathways are impaired, as for example, by HIV. Research has shown
that reduced intracellular GSH is the "direct and early consequence of
retroviral infection". Intracellular GSH has a powerful influence on how
well T- and B-lymphocyte cells function and on the production of phagocytes
(macrophages, monocytes and neutrophils). NAC has been shown to block
production of the AIDS virus in-vitro.
3. Detoxification & Chelation. Sulphydryl groups protect
against toxins. SH groups react directly with many poisons, including
herbicides, drugs (acetaminophen), environmental pollutants such as carbon
tetrachloride, microorganisms including E. coli and aflatoxin, and against
heavy metals. Indirectly, NAC helps with detoxification by producing optimal
amounts of GSH for conjugation reactions, making harmful compounds less
toxic.
NAC is approved as a drug in some European jurisdictions for use in
preventing liver damage from acetaminophen overdose.
4. Respiratory effects. NAC has been used for over 30 years
as a mucolytic in persons having bronchopulmonary diseases including chronic
bronchitis, cystic fibrosis, asthma, sinusitis, and pneumonia. NAC helps
reduce the viscosity of mucus so that it may be more easily coughed up. NAC
accomplishes this by converting the disulphide bond of the mucoproteins into
sulphydryl bonds and cleaving the mucoproteins into smaller molecules.
Recently, a number of studies have appeared studying the role of NAC in
preventing influenza. In a 1991 Italian double-blind, placebo-controlled
study of 262 patients with a susceptibility to influenza, NAC dosages of
600mg twice a day resulted in only 29% developing flu-like clinical
syndrome, compared to 51% of placebo-treated subjects.
Although the body's intestinal absorption of NAC is both rapid and almost
complete, its bioavailability (the amount that actually enters the
bloodstream) is quite low - approximately 4-10%. This is because the
first-pass metabolism of NAC by the cells of the small intestine and liver
result in the incorporation of NAC into peptide chains and the formation of
a variety of metabolites. Furthermore, NAC levels peak in the bloodstream
less than one hour after oral ingestion and have a plasma half-life of
approximately 2.15 hours. In order to overcome this problem, NAC's
antioxidant and cardio-protective abilities have been enhanced by its
infusion to a time-released, sustained delivery system that more than
triples NAC's ability to stay in the bloodstream and prolong its benefits
accordingly.
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