Unfortunately, there is a lack of clinical research supporting the efficacy of Chanca Piedra for the majority of it uses. There has been no single constituent or chemical isolated as responsible for its immense and positive health effects. The whole plant is used medicinally, and like so many natural remedies, may remain a medicine based on history and observation, as opposed to clinical research.

Chanca Piedra is also used as a potent detoxification aid, primarily due to its effect on liver function. It has been shown to help support healthy liver function and protect the liver against cellular damage. Chanca Piedra has been used to treat jaundice, anemia as well as protect against the incidence of liver cancer and liver damage due to alcohol, including fatty liver. It is a bitter herb, meaning it helps to stimulate digestive enzymes and the secretion of bile from the liver and gallbladder. As such, Chanca Piedra has been used to stimulate and promote healthy digestion and elimination, relieve dyspepsia and expel gas and bloating. It's bitter properties may also play a part in its anti-diabetic action, as well. There are some animal studies on the blood sugar regulating effect of Chanca Piedra. Although further human trials need to be conducted, this has great promise for diabetic patients having difficulty with glucose control.

Chanca Piedra acts as an effective but mild diuretic and as such, has the ability to exert hypotensive actions, lowering blood pressure. It is also believed to have cholesterol lowering effects. Chanca Piedra has both antibacterial and anti-viral properties. It has been used for a variety of urinary tract infections, and STI's, as well as studied for its potential in the treatment of hepatitis and HIV viruses.

Chanca Piedra is available as a supplement in capsule or tincture form. The loose dried plant can also be made into a tea. There is little information on specific dosage recommendations, although some literature states 2-3 g/day is a therapeutic dose. Chanca Piedra is contraindicated in pregnancy and during breast feeding. Some data suggests it may have an antifertility effect and until further studies are conducted, it is not recommended for women seeking pregnancy. Due to its medicinal effects, individuals currently taking medication to lower blood sugar and blood pressure, including diuretics, should be under the supervision of a health care practitioner if taking Chanca Piedra concurrently.