DMG is a derivative of the amino acid glycine, as well as a building block for methionine, choline and many other hormones and neurotransmitters. It can be found in small amounts in a variety of whole grains, brewer's yeast, pumpkin and sunflower seeds and beef blood or by taking DMG supplements.

What Is DMG?

As a water-soluble amino acid, it is absorbed through the small intestine and metabolized in the liver. DMG has two methyl groups attached to it, and here is where it loses its first, becoming sorcosine. It eventually can donate both methyl groups to folate, in the form of tetrahydrofolate (THF), enhancing the body's ability to use folate, while enhancing folate activity. In the case of Autism spectrum disorders (ASD) and ADD/ADHD, by both enhancing folate metabolism and the production of other forms of folate, DMG leads to enhanced cellular perception and response and allows neuronal cells to better pay attention to incoming signals, all processes that are impaired if DMG is deficient.

Key Health Benefits of DMG Supplements

Cholesterol Support

DMG's uses are widespread, from lowering cholesterol and normalizing blood pressure and blood sugar to being indicated in the treatment of epilepsy, ADD/ADHD and Autism spectrum disorders, as well as being known to enhance oxygen utilization in the body.

Antioxidant Properties

DMG is also a potent antioxidant or free radical scavenger, improving both circulation and oxygenation of blood, thereby increasing cardiovascular function. Studies dedicated to this use of DMG are showing promising results in terms of increased athletic performance. 

Liver Detoxification

Having an affinity for the liver, the antioxidant and anti-inflammatory capabilities of DMG have been shown to enhance and protect liver function, optimizing detoxification. DMG has been used to help alcoholism and drug addiction for these reasons. DMG has also been gaining attention for its immune-supporting abilities, as well as its potential for decreasing stress by regulating stress hormone production.

Final Insights, Considerations & Supplement Varieties

Overall, more studies need to be done, dedicated to the use of DMG in the treatment of a plethora of health concerns. Currently, there is not enough information to give a general recommendation in terms of a range of doses. This is better determined based on the need and condition to be treated. Like most B vitamins approx. 50-300 mg/day is generally recommended for adult usage. 

DMG can be found in sublingual tablets, and capsules, and included in many combinations for cognitive support. It is not meant for long-term use, as of yet, and due to a lack of information, it is best to avoid it during pregnancy and breastfeeding. If high doses are recommended by your healthcare practitioner, it is advised to start low and gradually build up.