Edta Supplement Uses & Varieties
Updated Feb. 19th, 2025 | Read Time: 3 Minutes | What You Will Learn:
- Understanding Your Body's Natural Chelation Process
- When Is An EDTA Supplement Recommended?
- Main Cautions & Concerns With EDTA Supplement Therapy
- Types of EDTA Supplements Administered By Healthcare Practitioners
- Nutritional Information
- Reader Comments (4)
Chelation therapy involves the use of oral or IV substances that bind (or chelate) metal ions, making them inactive or impairing their ability to react with other elements or ions so they can be excreted from the body. Heavy metal toxicity can have several detrimental effects on health. Among other pathologies, it is thought to play a role in Atherosclerosis and Heart disease, Autism, Allergies, Rheumatoid arthritis, Candida, MS, Lupus, Leaky gut, Anxiety and Depression. EDTA sodium supplement therapy is a chelator specific for the removal of such elements as Ca, Mg and Aluminium. EDTA Calcium is used primarily for the chelation of lead.
Calcium, magnesium and phosphorus are considered major minerals because you require a significant amount for many essential processes within your body. Other minerals which are also essential in smaller amounts, also known as trace minerals/elements, include iron, copper, chromium, iodine, manganese, fluoride, molybdenum, selenium and zinc. When any of these elements are overly abundant in the body, pathology ensues. Some of the more commonly encountered "bad" heavy metals, which can be found in high amounts in the body and can seriously compromise health, include arsenic, lead, mercury, cadmium, aluminium and iron, this is where chelation therapy comes in.
Understanding Your Body's Natural Chelation Process
Under normal circumstances, your body will try to eliminate lead via glutathione from the liver. The problem with your natural chelation process is that the bond between glutathione and lead is not very strong. If an individual has anything less than optimal digestive functioning, the lead-glutathione complex is much more likely to break apart in the gut. The lead is then reabsorbed, the glutathione excreted and the liver is forced to use up more of its essential glutathione stores to attempt to remove the lead again. This ineffective cycle continues and significantly lowers your liver's glutathione stores, as well as allowing lead to build up in the system. EDTA waits in the gut and binds to free lead (broken up from glutathione) or the lead-glutathione complex to ensure excretion from the body.
When Is An EDTA Supplement Recommended?
An EDTA sodium supplement is used by alternative medical practitioners primarily for the treatment of atherosclerosis. The mechanism of action is poorly understood, although it is generally accepted that sequestering calcium and, therefore, lowering the serum calcium level, forces calcium to be released from plaques in the blood vessels, breaking up the plaque in the process. One of the concerns with EDTA is that the rapid removal of calcium can lead to arrhythmia or respiratory arrest.
Since calcium is an element that is essential to many vital processes within the body, there is also some concern with EDTA removing too much of a good thing. Deaths have been reported due to cardiac arrest caused by hypocalcemia (lack of/insufficient calcium in the blood). Practitioners must also be careful not to overwhelm excretory routes when dealing with any kind of chelation therapy. Kidney functioning must be monitored closely.
Main Cautions & Concerns With EDTA Supplement Therapy
EDTA, like any form of chelation therapy, must be administered by a healthcare professional slowly and steadily to prevent injury to the kidneys. The potentially dangerous side effects of chelation therapy have certainly made this form of complementary medicine one of the more controversial.
Types of EDTA Supplements Administered By Healthcare Practitioners
EDTA can be found in both an oral form and can be injected via IV by certified parenteral therapists. The oral form of EDTA is both less expensive and less harmful, but unfortunately also much less effective and may be recommended more as a preventative or an adjunct to a set of IV treatments.




I have been taking oral EDTA, and am concerned about the demands it places on the kidneys- is it recommended to take a week off occasionally, or can it be taken every day? Could you please recommend a supplement routine for replenishing minerals while taking it. Thank you-
Hello Norman,
Thank you for enjoying our articles and for your questions. Every person is different; however, a general rule is to not take a detoxing supplement such as EDTA for more than a week unless otherwise stated on the manufacturer's label or by your health care practitioner. We would recommend you speak to a naturopath to come up with the best protocol for your specific health concern and situation.
Stay well & have a healthy day.
In college, one of the labs that I worked in used a chelator of heavy metals in order to combat disease progression in a mouse model of Alzhiemer's disease. I think that chelation, as a therapy, could be valid for use in numerous health conditions, though more research is warrented. I had never heard of EDTA sodium supplement therapy and did not know that EDTA was a chelator specific for the removal of such elements as Ca, Mg and Aluminium. I will be reading more on EDTA chealation therapy and thank you for introducing me to the concept. I'm curious what research on it has emerged since your article!
Hello Rachel,
Thank you for sharing your in lab experience with chelation and how you applied it to your studies. We're glad you enjoyed our article on EDTA and were able to expand your knowledge on EDTA chelation therapy and it sparked further learning for you.
Have a healthy day!