Nitric Oxide (NOX)

How Does Nitric Oxide Support Circulation?

Nitric oxide (NO) is a fascinating molecule with a wide range of physiological and biochemical functions. It is a colourless, odourless gas synthesized from the amino acid L-arginine in a reaction catalyzed by the enzyme nitric oxide synthase (NOS). Nitric oxide is a highly reactive molecule, and its discovery in the late 20th century revolutionized our understanding of vascular biology and has had far-reaching implications for medicine and physiology. Read more >

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  1. L-Arginine 500mg - 90 V-Caps
    500 MG L-ARGININE FROM NATURAL FACTORS This amino acid is known for its ability to promote strength and endurance by maintaining the formation of nitric oxide in the body. Natural Factors L-Arginine provides 500 mg per capsule and may be helpful for a number of health concerns. Studies show that regular supplementation with L-Arginine...
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  2. L-Arginine 1,000mg - 180 Tabs
    1000 MG L-ARGININE FROM NATURAL FACTORS This amino acid is known for its ability to promote strength and endurance by maintaining the formation of nitric oxide in the body. Natural Factors L-Arginine provides 1000 mg per capsule and may be helpful for a number of health concerns. Studies show that regular supplementation with L-Argin...
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  3. Neo40 Daily - 30 Lozenges
    HumanN Neo40 Daily is a breakthrough formula helps your body naturally increase Nitric Oxide levels, thus helping improve circulation, supporting the cardiovascular system and improving performance in adults over the age of 40. Neo40 Daily has been shown to reduce important cardiovascular risk factors, such as inflammation, triglycerid...
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  4. L-Arginine + L-Ornithine 500mg/250mg - 100 Caps
    HGH SUPPORT FORMULA WITH ARGININE & ORNITHINE. As we get past age 35, our body's production of growth hormone declines, eventually to less than 10% of what it once was. The amino acids l-arginine and l-ornithine help to optimize your own body's natural hgh production without the side effects or high expense of synthetic growth hormone...
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  5. L-Arginine 500mg - 250 Caps + BONUS
    500MG ACTIVE ARGININE in the superior "L" form. Arginine is considered an essential amino acid, which means that our bodies can not naturally produce it. However studies show that, for some individual's supplementation may offer an array of health benefits. Derived from natural sources, Now's arginine amino acid is free of binders and...
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  6. L-Arginine 500mg Free Form - 100 Caps
    500MG ACTIVE ARGININE in the superior "L" form. Arginine is considered an essential amino acid, which means that our bodies can not naturally produce it. However studies show that, for some individual's supplementation may offer an array of health benefits. Derived from natural sources, Now's arginine amino acid is free of binders and...
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  7. L-Arginine 1,000mg - 120 Tabs
    1000MG L-ARGININE FREE FORM AMINO ACID FROM NOW FOODS. This double strength free form amino, L-Arginine plays an important role in vascular health, immune function, growth hormone production and more. Providing a maximum 1000mg dosage per cap Now's L-Arginine looking potent support. L-Arginine is needed by the body to synthesize nitri...
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  8. L-Arginine Powder - 454g
    100% PURE-FREE FORM L-ARGININE POWDER FROM NOW FOODS. L-Arginine plays an important role in vascular health, immune function, growth hormone production and more. Now's L-Arginine powder is easily absorbed providing 4.6g (2 teaspoons). L-Arginine is needed by the body to synthesize nitric acid, which in turn helps arterial walls relax ...
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  9. L-Arginine 500mg - 100 Caps
    500 MG L-ARGININE FROM NEW ROOTS HERBAL Considered an essential amino acid, L-Arginine has a number of important functions in the body. Research suggests supplementation may be useful for those concerned with weight loss and muscle gain; immune function and growth hormone production. It also has shown to be helpful to men concerned w...
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  10. L-Arginine 1,000mg - 90 Tabs - Sisu
    L-ARGININE FROM SISU. Arginine is an amino acid which has a number of functions in the body. Sisu L-Arginine provides 750 mg per capsule and is recommended to help improve exercise capacity associated with recovery after disease. Arginine can also be used a diuretic, to increase production of growth hormone and help maintain a healthy...
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Nitric Oxide Supplements & Circulation

Nitric oxide (NO) is a fascinating molecule with a wide range of physiological and biochemical functions. It is a colourless, odourless gas synthesized from the amino acid L-arginine in a reaction catalyzed by the enzyme nitric oxide synthase (NOS). Nitric oxide is a highly reactive molecule, and its discovery in the late 20th century revolutionized our understanding of vascular biology and has had far-reaching implications for medicine and physiology. Nitric oxide and nitric oxide supplements are known to support your health in many ways including heart and circulatory health.

How Your Body Makes NO

The body's most well-known source of nitric oxide is the endothelium, which is the inner lining of blood vessels. Endothelial cells produce nitric oxide in response to various stimuli, including shear stress from blood flow, acetylcholine, and certain hormones. This endothelial NO helps regulate blood vessel tone and dilates blood vessels, thus increasing blood flow. This function is vital for maintaining healthy blood pressure and ensuring proper blood supply to tissues.

Neurons in the central and peripheral nervous systems also produce NO – known as neuronal nitric oxide, which functions as a neurotransmitter, aiding in the transmission of signals between nerve cells. In the brain, nitric oxide plays a role in memory formation, learning, and other cognitive functions.

In addition, immune cells, such as macrophages and neutrophils, can produce NO in response to infection and inflammation. This type of nitric oxide, known as inducible NO, helps the immune system combat pathogens.

However, if your body doesn't produce adequate amounts of nitric oxide on its own, supplements may be beneficial.

Various Nitric Oxide Supplements - Potencies, Forms & Formats

Nitric oxide is widely available in supplement form, typically sourced from the amino acid L-arginine or its precursor, L-citrulline. L-arginine can be converted into nitric oxide through synthesis when ingested. On the other hand, L-citrulline can indirectly boost nitric oxide production by being converted into L-arginine within the body, providing a sustained source for nitric oxide synthesis. NO, once produced, plays a crucial role in dilating blood vessels, improving blood flow, and supporting various physiological functions, making it a popular dietary supplement for enhancing cardiovascular health and exercise performance.

Nitric oxide supplements come in various forms, including capsules, powders, and liquids. Typical dosages vary depending on the product and individual needs but range between 1,000 to 3,000 mg (of L-arginine, L-citrulline, or a combination of both), taken 30 minutes to an hour before exercise. If you're using NO for overall cardiovascular health or other reasons other than exercise, it's recommended to take it before meals.

Key Benefits of NO Supplements On Your Health

  • Vasodilation – Nitric oxide supplements are a potent vasodilator that relaxes and widens blood vessels. This vasodilatory effect helps regulate blood pressure by reducing resistance to blood flow. Dysfunctional nitric oxide production can lead to conditions like hypertension.
  • Neurotransmission – NO functions as a neurotransmitter in the nervous system, facilitating communication between neurons. It is involved in memory, learning, and synaptic plasticity processes.
  • Immune Response – Nitric oxide produced by immune cells is part of the body's defence against pathogens. It acts as a cytotoxic agent, helping to destroy bacteria, viruses, and other microorganisms.
  • Platelet Function – NO inhibits platelet aggregation, which prevents blood clot formation and helps maintain proper blood flow.
  • Anti-inflammatory Effects – Nitric oxide has anti-inflammatory properties and can help modulate the body's immune response to reduce tissue damage during inflammation.
  • Erectile Function – In the male reproductive system, NO plays a vital role in the relaxation of smooth muscle in the blood vessels of the penis. This allows for increased blood flow, leading to erections. Medications like Viagra work by enhancing the effects of nitric oxide.
  • Cell Signaling – Nitric oxide is a signalling molecule in various cellular processes, influencing gene expression, cell growth, and differentiation.
  • Oxygen Transport – In the lungs, nitric oxide binds to hemoglobin, increasing its affinity for oxygen and improving oxygen transport in the bloodstream.

Who Would Benefit From Nitric Oxide Supplements?

NO supplements can be beneficial for a wide range of individuals. Athletes and fitness enthusiasts often use these supplements to enhance their exercise performance and endurance, as nitric oxide helps dilate blood vessels, increasing blood flow to muscles. This improved circulation can also benefit those with cardiovascular conditions, aiding in the management of blood pressure and overall heart health. Additionally, individuals seeking cognitive enhancement may find nitric oxide supplements appealing, as they promote better blood flow to the brain, which can improve cognitive function, especially in those with cognitive impairment and various forms of dementia. Furthermore, those looking to address erectile dysfunction may find nitric oxide's role in vasodilation helpful for improving blood flow to the genital area.

Things To Consider When Using Nitric Oxide

While generally well tolerated, some individuals may experience headaches, dizziness, or nausea when taking nitric oxide. In such instances, reduce dosage or discontinue use. Additionally, nitric oxide should be used with caution in those with certain underlying medical conditions, such as chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis, as it may worsen their respiratory symptoms. 

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