Griffonia seeds are the plant source for most of the 5-HTP found in supplements.
Griffonia: A Natural Boost For Cognitive Health
Updated Jul. 22nd, 2024 | Read Time: 2 Minutes | What You Will Learn:
- Key Health Benefits of Griffonia
- Mental Health Benefits
- Weight Loss Benefits
- Age-Associated Insomnia
- Griffonia Supplement Options & Shopping Tips
- Nutritional Information
- Reader Comments (2)
The seeds of the African Griffonia shrub (Griffonia simplicifolia) have long been used as a source of 5-HTP. 5-HTP stands for 5-hydroxytryptophan, which is a chemical naturally synthesized from tryptophan by your body. From this state, 5-HTP can be converted directly into our relaxing brain hormones serotonin, and melatonin.
Key Health Benefits of Griffonia
Mental Health Benefits
The main compound in Griffonia, 5-HTP, helps to dilate the blood vessels in the brain and thus can help to prevent migraines. When converted to serotonin, it helps to balance mood and alleviate symptoms of depression. In fact, in research studies, 5-HTP was found to be equal or better in the treatment of depression than tricyclic antidepressants and Prozac!
Weight Loss Benefits
A deficiency of serotonin in the brain can lead to emotional overeating and then to obesity. Supplementing with Griffonia, as a source of the building blocks of serotonin can help to reduce emotional and stress-related food cravings and overeating.
Age-Associated Insomnia
As you age, the melatonin production in your brain declines naturally. Supplementing with this nutrient provides a source of 5-HTP, which can support healthy melatonin production.
Griffonia Supplement Options & Shopping Tips
Generally, these supplements will be standardized by their content of 5-HTP. The dosage is usually standardized to provide somewhere between 50 and 300mg of 5-HTP daily.
To allow your body to adapt, it is a good idea to slowly increase your dosage over a few weeks until you achieve the desired dose. Taking Griffonia supplements with carbohydrates like juice can help to speed its absorption. Be sure to read the important information below for safety tips.




It seems my inbox is always stuffed with advertisements for nootropics, none of which I've purchased, by the way. I have seen Lion's Mane, Ashawaganda, L-theanine, and...more unusual ingredients too. But, I have yet to see Griffonia. The 5-HTP content sounds like a huge benefit for a nootropic formulation. I was wondering why I have not seen it around in supplements but you answered the quesion for me in the end with the important information section: I had never heard of seretonin sickness before and there are quite a few side effects and medication interactions to be aware of taking Griffonia!
Hello Rachel,
Thank you for your comment and learning about Griffonia with us. Indeed, too much serotonin can be unhealthy and toxic; therefore, those taking medications that boost serotonin should consult their health care practitioner before taking certain supplements. If you'd like to learn more about serotonin's role in the body, check out this video on our Youtube channel: https://www.youtube.com/watch?v=Nl1i8Ra04QA
Have a healthy day