What Is Vitamin B-6 P5P?

The vitamin pyridoxine is commonly known as vitamin B-6, and is involved as a cofactor in a number of different enzymatic processes in the body. Active B-6 in its coenzyme form P5P, serves in more functions in the body than any other single nutrient. It is particularly important for protein metabolism, and it also plays a role in blood sugar regulation. B6 can be used to treat anemia, allergies, arthritis, asthma, kidney stones, pregnancy-related nausea and multiple sclerosis (MS).

Symptoms of Vitamin B-6 Deficiency

A lack of sufficient B6 can appear as confusion, depression, irritability and mouth and tongue sores. It can also present as anemia, headaches, flakey skin, and even as carpal tunnel syndrome. Because of the fortification of processed foods, vitamin B6 deficiency is rare in North America.

Absorption of P5P

Vitamin B6 is absorbed in the small intestine and is dephosphorylated prior to absorption. This means that most B6 taken in its active form (P5P / PLP) will be converted back to its pyridoxal form prior to active absorption in the gastrointestinal tract. Once absorbed, it is converted back to P5P, its active form. Some people may lack this conversion enzyme and may benefit from higher doses of directly supplemented P5P that will bypass the transporter molecule and be absorbed through diffusion. Most people can benefit from supplementation of either form of vitamin B6.

Vitamin B-6 P5P Supplementation

P5P can be found in a number of different supplements including some B complexes, as well as PMS, cardiovascular, brain health, and mood balancing formulas. In general, it can be dosed at the same levels as pyridoxine. Thus, between 50 and 100mg per day is generally sufficient. For more information on dosing.

Important Information

B6 is depleted by antidepressants, estrogen, oral contraceptives, some antibiotics, and alcohol. Cortisone and diuretics block the absorption of B6. Diets high in protein require a larger B6 intake to allow for proper digestion and utilization. Prolonged excessive intake of B6 (1-6g per day for more than a year), can result in sensory neuropathy and loss of control of bodily movements. Doses exceeding 400mg per day are not recommended. Parkinson's patients on dopamine therapy should not supplement with B6, and diabetics should monitor their blood sugar levels during supplementation as their insulin dosage may need to be lowered.