Methylcobalamin is a bioavailable form of Vitamin B-12. This form tends to be more expensive to make and thereforeless often seen in multi-vitamins or B complex supplements than its counterpart cyanocobalamin. This form of vitamin B-12 is considered superior because it is easier for your body to absorb; giving you more of its benefits.
Understanding Methylcobalamin vs Cyanocobalamin
When the cyanocobalamin form of B-12 is taken, the liver has to convert it to methylcobalamin. This conversion process requires the antioxidant L-glutathione, which can often be low in many individuals; therefore, this conversion process may be significantly impaired in individuals with liver pathologies. In cases like these, supplementation with methylcobalamin is necessary.
Key Health Advantages of Methylcobalamin
Methylcobalamin has an affinity for the liver, the brain and the nervous system. It is the form that is active in your central nervous system and strongly responsible for nervous system health. Signs of methylcobalamin deficiency in the nervous system include tingling, numbness, loss of sensation or burning sensations, muscle cramps, or diminished reflexes. For these reasons, it is commonly used to help with symptoms associated with peripheral neuropathy or diabetic neuropathy. It is also more recently being studied for its support in amyotrophic lateral sclerosis (ALS). Also related to brain function, this form of B-12 plays a role in vision, particularly in improving and maintaining visual accommodation.
Methylcobalamin has been most studied in terms of its impact on sleep. Although the exact mechanism is unknown, it is thought that methylcobalamin is needed for the synthesis and diurnal secretion of melatonin. The use of this form of B-12 enhances light sensitivity, normalizes circadian rhythms and is often associated with improved sleep quality, a more rested feeling upon waking and possibly a decreased sleep requirement. There is also evidence to show that along with these findings, 24-hour cortisol levels and temperature regulation were also connected to the use of methylcobalamin.
Shopping For & Taking Vitamin B-12 Supplements
Vegetarians or vegans often require a form of B12 supplement as it is naturally present in only red meat, poultry, fish, eggs, milk and milk products. The optimum dosage for clinical effect is anywhere from 1000-6000 mcg, although the RDI is much lower at only 6 mcg. Consult your healthcare provider to see what dose is right for you. Methylcobalamin can be taken orally, intramuscularly, or intravenously.
