Phosphatidyl Serine (PS)

Phosphatidylserine Supplements

Phosphatidylserine (PS) is a phospholipid that is an important component of cell membranes in the human body and is especially concentrated in brain cells. It is crucial to maintaining cell membrane structure, integrity, and function. Moreover, phosphatidylserine is involved in several cellular processes, including signal transduction, neurotransmitter release, and ion transport across the membrane. In addition to its structural role, phosphatidylserine supplements have significant cognitive benefits, including improving memory, attention, and mental performance. It has also been shown to promote healthy aging and reduce the risk of cognitive decline.

While some phosphatidylserine is produced by the body, research has shown that our levels naturally decline with age. PS can also be obtained through diet, particularly organ meats (e.g., liver), mackerel, herring, and white beans. However, it is not present in high quantities in most commonly consumed foods. In fact, the amounts of PS in these foods are relatively small. Indeed, dietary studies have shown that most adults' average daily intake of PS from food is roughly 130-250mg. However, higher doses ranging from 300-600mg are necessary to achieve beneficial effects. This is where PS supplements come in. They are widely available in health food stores and online supplement retailers and can easily compensate for the PS lacking in our everyday diet.

Benefits of Phosphatidylserine Supplements

• Helps Treat ADHD, Alzheimer's, Anxiety, Depression, Multiple sclerosis (MS), and Stress-Related Conditions
• Improves Memory & Concentration
• Promotes Healthy Cognitive Function
• Protects Brain Cells

Who Needs Phosphatidylserine?

PS supplements can be used to help support health in several ways, including:

Memory and cognitive function – Studies have shown that phosphatidylserine supplementation can improve memory, attention, and mental performance, particularly in individuals with age-related cognitive decline or certain neurodegenerative conditions.

Stress reduction – Phosphatidylserine helps regulate the body's response to stress by modulating cortisol, our primary stress hormone. More concretely, PS supplementation helps lower cortisol production.

Exercise performance – Evidence suggests phosphatidylserine supplementation enhances exercise capacity and reduces exercise-induced stress. It can also help reduce muscle damage and inflammation, improving recovery and overall performance.

Phosphatidylserine Supplements

Phosphatidylserine supplements are typically derived from soy or bovine sources. They are widely available in capsules, softgels, tablets, powders, chews, and gummies for those who have trouble or are tired of swallowing pills. These come in a range of different potencies; the recommended daily dose will vary according to the intended purpose for which you are taking the supplement. For cognitive enhancement, the recommended dose is typically between 100 mg and 300 mg daily, while older adults experiencing age-related cognitive decline are usually suggested a higher dose ranging from 300 mg to 600 mg daily, divided into multiple doses.

Final Thoughts 

Phosphatidylserine is generally well tolerated, but some individuals may experience side effects. These may include:

• Gastrointestinal issues such as stomach upset, bloating, gas, and diarrhea. Side effects are typically temporary and mild.
• Allergic reactions such as rash, itching, swelling, or difficulty breathing.

It's also important to note that PS may interact with certain medications, including acetylcholinesterase inhibitors (used to treat Alzheimer's disease), nonsteroidal anti-inflammatory drugs (NSAIDs), and certain antidepressants. Consult with your health care practitioner if you take any prescription medications to assess potential interactions.