3 capsules contain:
- 100mg
- Vitamin C
Non-Medicinal Ingredients:
Calcium Phytate (1500mg per serving), Sodium Stearyl Fumarate Capsule: Hypromellose
Calcium Phytate (1500mg per serving), Sodium Stearyl Fumarate Capsule: Hypromellose
Format
Veggie Caps
90vcaps
Dosage
Take one capsule three times daily on an empty stomach, or as directed by a qualified health care practitioner.
Important Information
Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. Consult a health care practitioner prior to use if you are pregnant or breastfeeding. This product contains a corn derived ingredient, do not consume if you have such allergy.
Highlights
- Inhibits cellular proliferation and de-differentiation.
- Free iron chelator.
- Naturally fortifies cellular defenses.
- From Rice bran extract..
- 100% vegan.
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Manufacturer Info
AOR Canada is the innovative formulators of Canada’s best-selling antioxidant support, AOR Advanced B Complex and AOR Tri-B12. They are also known for their top bone health supplements, Ortho Adapt and Bone Basics. You can also SHOP AOR's Nattokinase, and trusted Curcumin Ultra, Curcumin Active and Curcumin95 inflammation support at National Nutrition.ca. AOR are leaders in natural health with innovative product development.
What is IP6
Chemically, Inositol Hexaphosphate (IP6) is a central inositol ring structure surrounded by six phosphate groups. IP6 and its metabolites are found in every mammalian cell. A University of Maryland Medical School researcher, Dr. Shamsuddin, and his colleagues, have found that this common, naturally occurring substance can shrink tumors, stop their growth, and may even induce differentiation, transforming unhealthy cells into normal, healthy ones. .
IP6 is normally found in high concentration in many fibers, and some authors have suggested that IP6 may be one of the protective compounds that give fiber its anticancer benefits. For instance, in Finland, a country that consumes both a high fat diet and plenty of fiber, where a typical diet is high-fat, low-fiber. More interestingly, the Danes consume double the total fiber of Finns, and yet the Finns have only half the rate of unhealthy colon cells. One possible explanation for this paradox is that the sources of fiber in the Finnish diet yields considerably more IP6 than do those used by the Danes.
Shrinking Tumors
In a study of human liver ells transplanted into mice that were subsequently treated with IP6, the researchers found that IP6 slowed or stopped the growth of unhealthy liver cells and shrank existing tumors three to four fold. In one human liver cell study, Shamsuddin's team treated human hepato-carcinoma cells with varying doses of pure IP6. The result was partial to complete inhibition of cell growth and proliferation. Treated cells transplanted into mice produced no tumors over the 41 days of the experiment, while 71% of control mice developed tumors. When these control mice were treated with IP6 for 12 days, their tumors weighed 3-4 fold less than before IP6 treatment, suggesting that IP6 is useful as a preventative and as a treatment.
Shamsuddin has tested IP6 on colon, lung, breast, prostate, leukemia, fibrosarcomas, and unhealthy muscle cells in test tubes and in experimental animals, including human transplanted into animals. In all types, whether IP6 is administered before, during, or after exposure to a carcinogen or the development of tumors, treated animals have shown fewer, smaller tumors with reduced growth rates.
Inducing Differentiation
Nearly every cell in the body contains the DNA for the entire organism, but a healthy cell only turns on a small portion of this DNA, so that a lung cell is different from a brain cell, a liver cell, or a red blood cell.
Mechanisms of Action
There are several probable ways that IP6 exerts its effects:
(1) Antioxidant Protection through Chelation:Antioxidants are believed to fight unhealthy cells in the body because they prevent free radical damage to DNA. Unbound iron (ferritin), though not a free radical itself, can be the catalyst for the deadly Fenton Reaction, in which iron reacts with the relatively harmless hydrogen peroxide (H2O2) and forms the highly reactive hydroxyl radical (OH.). IP6 chelates free iron, thereby preventing the hydroxyl radical production before it starts.
(2) Immune Function:Animal experiments conducted by Dr. Shamsuddin have clearly shown dramatic increases in the activity of Natural Killer Cells (NK) in animals treated with IP6. This increase corresponds neatly with decreased tumor incidence in treated animals, as one would expect, since NK cells' main function in the body is to seek out and destroy unhealthy cells and virus-infected cells.
(3) Cellular Signaling:The inositol phosphates (IPs) are involved in cellular signaling, regulating calcium balance within the cell and thus the rate of cell division. Dr. Shamsuddin has shown that IP6 administration both elevates the levels of several IPs within the cell and slows cell division.
(4) Gene Expression:IP6 appears to be a competitive inhibitor for the enzyme phosphatidylinositol-3 kinase (PI3K), which is the enzyme that activates activator protein 1 (AP-1). AP-1 is a protein transcription factor induced by asbestos and other unhealthy cell promoters, which binds to, and activates, known unhealthy cell genes such as c-FOS and c-JUN. IP6 has also been reported to up regulate expression of the tumor-suppression gene p-53, an exciting development indeed.
Although IP6 is found in a number of legumes and grains, the absorption from food sources is not always good, because the IP6 is tightly bound to elements within the fiber. This explains why pure, isolated IP6 has thus been shown to fight tumors more effectively than an equal amount of IP6 in fiber. IP6 should be taken between meals in order to ensure that it does not compete with such elements in food. Experts advise that consuming 2g of IP6 per day in supplemental form provides good "health insurance" to support natural cell defenses.
Chemically, Inositol Hexaphosphate (IP6) is a central inositol ring structure surrounded by six phosphate groups. IP6 and its metabolites are found in every mammalian cell. A University of Maryland Medical School researcher, Dr. Shamsuddin, and his colleagues, have found that this common, naturally occurring substance can shrink tumors, stop their growth, and may even induce differentiation, transforming unhealthy cells into normal, healthy ones. .
IP6 is normally found in high concentration in many fibers, and some authors have suggested that IP6 may be one of the protective compounds that give fiber its anticancer benefits. For instance, in Finland, a country that consumes both a high fat diet and plenty of fiber, where a typical diet is high-fat, low-fiber. More interestingly, the Danes consume double the total fiber of Finns, and yet the Finns have only half the rate of unhealthy colon cells. One possible explanation for this paradox is that the sources of fiber in the Finnish diet yields considerably more IP6 than do those used by the Danes.
Shrinking Tumors
In a study of human liver ells transplanted into mice that were subsequently treated with IP6, the researchers found that IP6 slowed or stopped the growth of unhealthy liver cells and shrank existing tumors three to four fold. In one human liver cell study, Shamsuddin's team treated human hepato-carcinoma cells with varying doses of pure IP6. The result was partial to complete inhibition of cell growth and proliferation. Treated cells transplanted into mice produced no tumors over the 41 days of the experiment, while 71% of control mice developed tumors. When these control mice were treated with IP6 for 12 days, their tumors weighed 3-4 fold less than before IP6 treatment, suggesting that IP6 is useful as a preventative and as a treatment.
Shamsuddin has tested IP6 on colon, lung, breast, prostate, leukemia, fibrosarcomas, and unhealthy muscle cells in test tubes and in experimental animals, including human transplanted into animals. In all types, whether IP6 is administered before, during, or after exposure to a carcinogen or the development of tumors, treated animals have shown fewer, smaller tumors with reduced growth rates.
Inducing Differentiation
Nearly every cell in the body contains the DNA for the entire organism, but a healthy cell only turns on a small portion of this DNA, so that a lung cell is different from a brain cell, a liver cell, or a red blood cell.
Mechanisms of Action
There are several probable ways that IP6 exerts its effects:
(1) Antioxidant Protection through Chelation:Antioxidants are believed to fight unhealthy cells in the body because they prevent free radical damage to DNA. Unbound iron (ferritin), though not a free radical itself, can be the catalyst for the deadly Fenton Reaction, in which iron reacts with the relatively harmless hydrogen peroxide (H2O2) and forms the highly reactive hydroxyl radical (OH.). IP6 chelates free iron, thereby preventing the hydroxyl radical production before it starts.
(2) Immune Function:Animal experiments conducted by Dr. Shamsuddin have clearly shown dramatic increases in the activity of Natural Killer Cells (NK) in animals treated with IP6. This increase corresponds neatly with decreased tumor incidence in treated animals, as one would expect, since NK cells' main function in the body is to seek out and destroy unhealthy cells and virus-infected cells.
(3) Cellular Signaling:The inositol phosphates (IPs) are involved in cellular signaling, regulating calcium balance within the cell and thus the rate of cell division. Dr. Shamsuddin has shown that IP6 administration both elevates the levels of several IPs within the cell and slows cell division.
(4) Gene Expression:IP6 appears to be a competitive inhibitor for the enzyme phosphatidylinositol-3 kinase (PI3K), which is the enzyme that activates activator protein 1 (AP-1). AP-1 is a protein transcription factor induced by asbestos and other unhealthy cell promoters, which binds to, and activates, known unhealthy cell genes such as c-FOS and c-JUN. IP6 has also been reported to up regulate expression of the tumor-suppression gene p-53, an exciting development indeed.
Although IP6 is found in a number of legumes and grains, the absorption from food sources is not always good, because the IP6 is tightly bound to elements within the fiber. This explains why pure, isolated IP6 has thus been shown to fight tumors more effectively than an equal amount of IP6 in fiber. IP6 should be taken between meals in order to ensure that it does not compete with such elements in food. Experts advise that consuming 2g of IP6 per day in supplemental form provides good "health insurance" to support natural cell defenses.
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