Oregon grape (Mahonia aquifolium) is an evergreen shrub closely related to Barberry. For more information on Barberry, please click here. Although it is called the Oregon grape, this plant is not a true grape (Vitaceae) family and has very different effects. The root has traditionally been used for hundreds of years by First Nations peoples in the treatment ofmany infections, as well as diarrhea and stomach ulcers. It is often used as an alternative to Goldenseal in herbal formulas when Goldenseal is not available, as both are rich in berberines. 

Compounds Found In Oregon Grape

Berberines

The main constituent of Oregon grape is berberine, which gives this herb its antimicrobial and anti-inflammatory capabilities. Berberines have also been found to benefit: diabetes, Alzheimer's, depression, and cardiovascular disease. 

Top Uses For Oregon Grape Supplements

Preventing Multi-Drug Resistant Bacteria

Interestingly, the active constituents in Oregon grape have been shown to inhibit the immunity of multi-drug resistant(MDR) bacteria, such as MRSA to antibiotics. These bacteria use a pump to shuttle the antibiotic back out of their cells as soon as it is absorbed. Oregon grape prevents the function of this pump, thus making the multi-resistant bacteria once again susceptible to prescription antibiotics. Because of this, it can be used in combination with antibiotics to help treat infections with these bacteria.

Psoriasis

It has been established by research that Oregon grape applied topically in a 10% concentration to psoriasis lesions can significantly reduce their severity and can improve the quality of life of psoriasis sufferers. Some evidence suggests that taking it internally may help as well. Further research is required, but this has interesting potential.

Tips For Taking Oregon Grape Supplements

Oregon grape can be found in capsules or tablets on its own or in combination formulas for antimicrobial, and anti-diarrheal purposes. It can also be found in skin creams for the treatment of psoriasis. The oral dosage has not yet been established by research, so following the manufacturer's label instructions is best practice.