Phenylalanine
Updated Nov. 11th, 2024 | Read Time: 2 Minutes | What You Will Learn:
- How Brain Chemicals Effect Your Health
- Dopamine
- Norepinephrine
- Hormones: Thyroid & Melanin
- Key Health Benefits of Phenylalanine
- Phenylalanine Supplement Options
- Cautions & Considerations
- Nutritional Information
- Reader Comments (2)
Essential amino acids are ones that the body cannot produce, and need to be taken in through the diet. Phenylalanine is one of these amino acids. It crosses the blood-brain barrier and is a precursor to the production of many brain chemicals, including dopamine and norepinephrine and hormones, including thyroid hormone and melanin (for skin pigmentation).
How Brain Chemicals Effect Your Health
Dopamine
Dopamine deficiency leads to Parkinson’s disease because the brain is unable to stop unwanted movement. Dopamine also regulates mood and appetite.
Norepinephrine
Norepinephrine promotes alertness.
Hormones: Thyroid & Melanin
Thyroid hormone sets the body’s metabolic rate thus influencing energy, mood, appetite, temperature and weight. Melanin deposits skin pigment and is deficient in the disease called vitiligo.
Phenylalanine is also involved in producing brain chemicals that regulate blood pressure, fluid balance, pain, and fat metabolism.
Key Health Benefits of Phenylalanine
This amino acid can be supplemented for the following conditions:
- Depression
- Schizophrenia
- Pain
- Vitiligo
- Parkinson’s Disease
- PMS
- Obesity
- Arthritis
- Menstrual Cramps
Phenylalanine Supplement Options
The biologically active forms of phenylalanine are D (painkiller), L-phenylalanine (makes proteins and brain chemicals), and DL (does both). They are commonly found in capsules. Aspartame contains phenylalanine and aspartic acid.
Take amino acid supplements at least 1/2 hour before or after a meal to maximize their absorption. If you take an individual amino acid supplement for longer than one month, add an amino acid complex to the protocol to prevent the deficiency of other amino acids.
Cautions & Considerations
The amino acids leucine, isoleucine, and valine compete with phenylalanine for absorption. This amino acid shouldn't be used by people with hyperactivity, phenylketonuria, migraines, anxiety, diabetes, high blood pressure, pigmented melanoma, and pregnant women.




I thought that L amino acids were the biologically active ones: is D-phenylallanine found naturally and if not, I am curious how it was discovered! Anyway, it is very interesting how the two stereoisomers can have such different biological effects (eg painkiller versus protein and brain chemical component). Also, thank you for reminding me that aspartame contains penylallanine and aspartic acid: I had almost forgotten that little factoid and like to stay up to date on sweeteners so good to know! :)
Hello Rachel,
Excellent comment and glad you enjoyed this article and re-learning some interesting facts. If you'd like to continue learning about sweeteners, check out this article: https://www.nationalnutrition.ca/articles/supplements/sugar-artificial-sweeteners-natural-sources/