Vitamin K (MK4)

What Is MK4 Vitamin K?

Did you know that Vitamin K consists of a group of structurally similar vitamins that include K1 (phylloquinone), K2 (menaquinones) and K3 (menadione)? While vitamin K1 can readily be found in plants such as green leafy vegetables like collard greens, kale, and spinach, humans can create the MK4 form of vitamin K2 by converting K1 to MK4 inside the body. Read more >

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Vitamin MK-4 For Bone Health

Did you know that vitamin K consists of a group of structurally similar vitamins that include K1 (phylloquinone), K2 (menaquinones) and K3 (menadione)? While vitamin K1 can readily be found in plants such as green leafy vegetables like collard greens, kale, and spinach, humans can create the MK4 form of vitamin K2 by converting K1 to MK-4 inside the body, which is beneficial for bone health. Vitamin K3, on the other hand, is a synthetic or artificially produced form of vitamin K, so we will put it aside for this article.

Vitamin K2 is central to blood clotting, heart health, and bone health. Unfortunately, many people do not consume enough vitamin K2-containing foods as part of the typical Western diet. This can have dire consequences for bone health, resulting in lower bone density and a higher risk of osteoporosis and fractures. Low vitamin K2 may also cause difficulties with blood clotting, heavy bleeding, and heart issues. In such instances, supplementation can help.

MK-4 is widely regarded as the most important of the K2 (menaquinone) vitamins. It has been shown to activate proteins that are involved in the utilization of calcium by the body, which not only allows us to build stronger and more resilient bones and teeth but also inhibits the accumulation of calcium in the soft tissues such as the arteries, so it benefits both bone and heart health. Studies on the MK-4 (menaquinone-4) form of K2 have shown it can both stop and reverse bone loss, grow more robust bones, and reduce fractures by more than 80%! Not convinced? Well, the use of MK4 is supported by over 25 clinical trials involving more than 7000 volunteers.

Benefits of MK-4 For Bone Health

  • Helps Grow Stronger Bones
  • Maintains or Increases Bone Density 
  • Prevents & Treats Osteoporosis
  • Reduces Fractures By More Than 80%
  • Stops & Reverses Bone Loss

Who Needs MK-4?

Generally, supplementation with vitamin K2 in MK-4 form is recommended to promote the optimal health of teeth and bones, help guard against the loss of bone mineral density and fractures, and prevent and treat osteoporosis. MK-4 may be especially beneficial for postmenopausal women, individuals with diagnosed bone loss, and those suffering from anorexia nervosa. Another exciting application for MK-4 supplementation is to improve energy utilization by increasing insulin sensitivity, enhancing athletic performance, and improving glycemic balance.

MK-4 Supplements For Bone Health

MK-4 supplements are readily available in health food stores and through supplement retailers in all sorts of delivery formats, including capsules (both gelatin-based and veggie caps), softgels, liquids, drops, and liposomal blends that promise better bioavailability and absorption. The potency of MK-4 supplements is usually in the 100–120 mcg range, though the total daily amount you need will vary based on the purpose for which you are supplementing.

Final Thoughts

Because of vitamin K's profound effect on blood coagulation, supplementing can antagonize the effects of blood thinners, including Warfarin. If you take Warfarin or other blood-thinning medications or anticoagulants, do not start taking vitamin K without consulting your healthcare practitioner.

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