Pure Encapsulations SAMe - 60 Caps

PURE ENCAPSULATIONS SAMe (S-Adenosylmethionine)
Enhanced-stability SAMe to support healthy mood balance and osteoarthritic joint comfort

Provides 200 mg per capsule of enhanced-stability form SAMe 

• Manufactured using a solvent-free manufacturing process


• Helps to promote healthy mood balance


• Helps relieve pain due to osteoarthritis


• Made with hypoallergenic, vegan ingredients

SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also promotes healthy mood balance, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood, believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and serotonin. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it supports joint flexibility and comfort in individuals with osteoarthritis as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.

Osteoarthritis (OA) is the most common type of arthritis
It affects almost all of us as we age. OA usually has a gradual onset and tends to begin after the age of forty. The knees, hips, fingers and spine are the most susceptible joints. This type of arthritis will affect one or only a few joints at a time, and usually won’t symmetrically affect both sides of the body at the same time (although that is possible). This is a degenerative condition that tends to worsen over time, especially with increased use of the affected joints.

How does it happen?
Most commonly, bouts of OA result from an injury to the joint, which causes some local damage that the body fails to properly repair. Unlike rheumatoid arthritis, the joint deterioration in OA is due to faulty or deficient repair of bone and cartilage in the joint. This can be due to lack of the essential nutrients required for repair, or due to faulty sensory and repair mechanisms in the body. For more information on joint function and the structure of the joint capsule, please see our Joint Health article.

Signs and Symptoms
The largest indicator of Osteoarthritis is a motion induced pain in the joints and stiffness that is worse after a period of inactivity such as when resting or upon waking. At first, there will likely not be any inflammation in the joint however as the condition continues the joint will become damaged and begin to swell and change shape. Surrounding muscles may spasm and many people report a grinding feeling in the joint upon moving. Eventually, the affected joint will emanate constant pain even when it is immobile. Most occurrences of osteoarthritis are not symmetrical and only affected one side, for example, the left hand and not the right. One small joint in a finger can be effected without causing pain in the other joints. When the arthritis is more widespread and symmetrical, it is more likely an inflammatory condition called: Rheumatoid Arthritis (RA).