AOR Ginkgo Biloba 100mg - 90 V-Caps

Ginkgo biloba, one of the best-selling herbs in the world, contains a variety of compounds, but the main active ingredients fall into two main categories:

1. Terpenoid Lactones
Terpenoid substances impart a strong, bitter flavor. Ginkgo Biloba 50:1 contains a minimum of 6% terpene lactones, considered the highest percent available.

2. Flavonoids (Antioxidant Potential)

a. Ginkgoflavonglycosides (also called heterosides). Ginkgo flavonoids are up to 10 times more potent than citrus bioflavonoids. Ginkgo Biloba 50:1 is standardized for 24% flavonoids. Some of the flavonoids found in Ginkgo biloba include quercetin, kaempferol and isorhamnetin.

b. Proanthocyanidins, which are ionized (negatively charged) flavonoids, are also found in pine bark, grape skin and grape seeds.

c. Other flavonoid groups found in minor quantities are coumarin esters and catechins.

The most potent and important compounds in Ginkgo biloba are the ginkgolides A and B. Ginkgo Biloba 50:1 is rich in Ginkgolides, containing a minimum of 0.8% the highest range available.
Studies by Casato, Doly, Fink, and others powerfully suggest that ginkgolide B is the most important component of Ginkgo biloba. Ginkgolide B has been isolated and studied as compound BN 52021 and shown to have biological effects. In fact, editor Pierre Braquet, Ph.D's review text on the effects of ginkgo is entitled "Ginkgolides and ginkgo flavonoids". According to Braquet, the world's leading authority on Ginkgo biloba, the extracts are 90% absorbed.

Origin

Ginkgo Biloba 50:1 begins with its plantation-grown leaves. Japan Greenwave carefully cultivates their own leaves on plantations using agricultural technology to produce leaves richer and more potent in ginkgolide B. No extraction technology can compensate for inferior plant material. Much of the original European research on Ginkgo biloba extract used Japan Greenwave leaves for their extractions.

Ginkgo Biloba 50:1 Extract:
Is rich in Ginkgolides A and B.
Is standardized to 24% Ginkgoflavonglycosides.
Contains 6% Terpene Lactones, including:
Ginkgolide A - 1.2% (minimum)
Ginkgolide B - 0.8% (minimum)
Ginkgolide C - 1.0% (minimum)
Bilobalide - 2.8% (minimum)
Uses plantation-cultivated leaves from Japan Greenwave.
Employs scientifically controlled standardized extraction, from leaf to extract, by Japan Greenwave.

Cognitive Benefits

Ginkgo biloba enhances cerebral microcirculation in the brain, keeping needed energy and oxygen flowing to the brain. Many controlled trials have demonstrated the ability of Ginkgo to support cognitive function.
A recent randomized, double-blind, placebo-controlled trial found that 4 weeks of treatment with gingko biloba extract in younger patients led to significantly superior measures of anxiety disorder or adjustment disorder with anxious mood compared to the placebo group.
A meta-analysis of nine studies concluded that gingko biloba extracts are beneficial in dementia.
A randomized, double-blind, placebo-controlled, parallel-group, multicenter study tested the effects of gingko biloba extracts for 52 weeks in Alzheimer patients with mild to severe dementia. In 202 patients, the extract appeared to be capable of stabilizing and improving the cognitive performance and the social functioning of demented patients. It has also been shown to delay the onset of Alzheimer's disease.
A randomized, placebo-controlled, double-blind study of 60 Alzheimer's patients compared Gingko biloba extract to the drug donepezil. After a 24 week supplementation period, Gingko biloba was found to be comparable to donepezil in its improvements compared to the placebo group, as assessed by the Clinical Global Impression score.

Ginkgo biloba is also useful for those whose mental faculties have not yet begun to decline:

A randomized, double-blind, placebo-controlled, parallel-group study gave Gingko biloba extracts to 60 healthy volunteers between 50 and 65 years of age. After 4 weeks, self-estimated mental health and quality of life were significantly better in the gingko group compared to placebo.
A placebo-controlled, double-blind, crossover study found that acute administration of gingko biloba (100-360 mg) produced a sustained improvement in attention in healthy young adults compared to placebo.



Gingko biloba has overall been found to be safe and well tolerated, although it does have several potential drug interactions to be aware of.

Cautions: Do not use if you are taking health products that affect blood coagulation (e.g. blood thinners, clotting factor replacements, acetylsalicylic acid, ibuprofen, fish oils, vitamin E) as this may increase the risk of spontaneous bleeding. Consult a health care practitioner prior to use if you are taking medications for diabetes, high blood pressure, or seizures, if you are pregnant, breastfeeding or for use beyond four weeks.