- 100mg
- Dried Vaccinium macrocarpon (Cranberry) juice
- 1000mg
- D-Mannose
Magnesium hydroxide, sodium stearyl fumarate, tricalcium phosphate,microcrystalline cellulose, distilled water and sodium carboxyl methylcellulose.
Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. Consult a health care practitioner prior to use if you are pregnant, trying to conceive, taking blood thinners or have a history of kidney stones, or if symptoms persist or worsen with use.
Tablets
120 Tabs
Take one to two tablets four to five times daily without food, or as directed by a qualified health care practitioner. Take with water.
- From Cranberry, Norwegian birch tree bark.
- Urinary tract infection support.
- Fights adhesion molecules.
- Fights urinary tract bacteria.
- With D-Mannose.
Innovative Formulas by AOR Canada found at National Nutrition
AOR Canada is the innovative formulators of Canada’s best-selling antioxidant support, AOR Advanced B Complex and AOR Tri-B12. They are also known for their top bone health supplements, Ortho Adapt and Bone Basics. You can also SHOP AOR's Nattokinase, and trusted Curcumin Ultra, Curcumin Active and Curcumin95 inflammation support at National Nutrition.ca. AOR are leaders in natural health with innovative product development. Read more >- Reviews
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Although urinary tract infections (UTIs) can involve a variety of different bacteria species (including Staphylococcus saprophyticus and some enterococci species), nearly all infections of the lower urinary tract and bladder are caused by a few strains of E. coli bacteria called uropathogenic Escherichia coli (UPEC). Various harmless strains of E. coli are normally present in the body - but they don't belong in the urinary tract.
If UPEC get into the bladder or the urethra, the body has ways of fighting them off - including the obvious method of simply flushing them out with the urine. But these bacteria have evolved ways of anchoring themselves to the cells of the urinary tract. The invading UPEC take advantage of receptors naturally found on the cells of the mucosal lining of the urinary tract. Receptors are like molecular "docking bays" for substances that the cells need for their normal growth and development. Like pirates in an old movie, UPEC use "grappling hooks" called type I pili to first hook on to these receptors, and then to invade the cell.
Once inside the cell, these pathogens can live and reproduce in safety, shielded from many of the body's defensive immune responses. In fact, they are so sophisticated that when the body detects that cells have been infected and activates the cell suicide program to destroy the bacteria, UPEC can actually flee the dying host cell before it is flushed out, and look for new cells to invade!
The Role of D-Mannose in the prevention and Treatment of UTI's
Pathogenic E. coli bacteria's pili "grappling hooks" are composed of long, fibrous chains of molecular "glue" called adhesin. The effective binding of these adhesin molecules depends on the chemical attraction that exists between them and the residues of a simple carbohydrate called D-Mannose on the cell surface receptors of the urinary tract host cells.
The chemical attraction between UPEC adhesins and D-Mannose is their strength - but it also provides a point of vulnerability. If you can interfere with the binding of adhesins to the D-Mannose residues in the receptors of your urinary tract cells, then you can also prevent UPEC from getting a foothold for adherence and infection. One way to do this, long known to work in a test tube, is by using D-Mannose itself. When isolated urinary tract cells are bathed in D-Mannose, it acts as molecular "chaff." The bacterial adhesins bind to the D-Mannose in their environment instead of to the D-Mannose residues on the cells. This gums up their pili and prevents them from hooking onto urinary tract cells.
It was discovered in the late 1980s that a small amount of D-Mannose is present in the urine normally, apparently acting as a defensive mechanism against pathogenic bacteria. When D-Mannose is taken as a supplement, much more of the carbohydrate passes through the urinary tract, strengthening this natural defense.
A decade after this discovery, Dr. Jonathan V. Wright of the Tahoma Clinic pioneered the use of D-Mannose supplements to fight off UTIs. For some years, he has been reporting the successful results that his patients have experienced in using D-Mannose to rid themselves of infection. Even patients who had remained infected after having been subjected to a wide range of potent, side-effect-inducing antibiotics have successfully rid themselves of chronic or acute infections using D-Mannose. Other nutritionally oriented physicians and health practitioners have since adopted Dr. Wright's protocols, and the feedback is uniformly excellent from UTI sufferers and their caregivers alike.
Again, not all UTIs are caused by UPEC. So if you try a course of D-Mannose and infection persists, it is likely not caused by these E. coli bacteria but by some other pathogen. In that case, don't just keep going on with the supplement in hopes that it will eventually "kick in:" discontinue use of D-Mannose and consult a physician for treatment appropriate to your case. But for the great majority of urinary tract infections, D-Mannose offers a safe, natural option with a simple, ingenious rationale, no known side-effects, and a great reported success rate.
Cranberry Extract for an Enhanced Effect
Cranberries have been used in the treatment of UTI for many years and are now regarded as a non-pharmaceutical approach for the treatment and prevention of simple UTI infections. Like D-Mannose, cranberries are effective in the treatment of the majority of UTI caused by by E.coli.
Cranberries and cranberry extracts acidify the urine, which reduces bacterial growth. Furthermore, cranberries also contain certain tannins called proanthocyanidins that have been shown to reduce bacterial adherence to the urinary tract wall. It has been shown that within 3 hours after ingesting cranberry, molecular changes in the adhesion apparatus used by bacteria to attach themselves to the urinary tract wall occur. This is a significant benefit in the treatment of UTIs as adherence is essential for infection.
If bacteria cannot attach themselves to the urinary tract wall, they cannot cause an infection. However, once attached to the urinary tract wall, bacteria cannot be removed by the body's normal clearing mechanisms. Studies have documented that drinking eight glasses of cranberry juice twice a day can eradicate most UTIs. If consumption is maintained, infection is unlikely to recur; a Harvard study has demonstrated that regular use of cranberry juice reduced bacterial growth in the urinary tract. Studies have demonstrated that infections can be reduced by over 50% in elderly women drinking 300 ml of cranberry juice per day. In general, cranberry tablets are more cost effective than cranberry juice in the treatment and prevention of UTI. UTI Cleanse Now with Cranberry contains a concentrated extract, the 400mg daily dose of this extract is equivalent to roughly 1 cup of cranberries.
A Superior Combination
UTI Cleanse Now with Cranberry combines two ingredients that are well known and highly effective for the natural prevention and treatment of UTI's, namely D-Mannose and Cranberry Extract. This superior and convenient combination provides a one-two punch for individuals battling recurrent urinary tract infections.
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