Estro Adapt - 60 V-Caps + BONUS

AOR's Estro Adapt

Estrogens are very important hormones. Although they are present in both men and women, their best known role is as the primary female sex hormones, and they are thus involved in the development of female characteristics and in the regulation of the menstrual cycle. Estrogens have over 400 different functions in the body, some of which include the maintenance of tissue strength, cardiovascular health, mood, bone health and vision.

However, there are many different kinds of estrogens, which can be confusing. The general term "estrogen" tends to be used to describe all types of estrogens, including naturally occurring estrogen produced in the body, estrogens produced by plants (phytoestrogens) and environmental estrogens (xenoestrogens). What is important to note is that while some estrogens are healthy and beneficial, other types can have negative effects.

For example, xenoestrogens, which are synthetic estrogens encountered in the environment, are particularly dangerous. These compounds can be present in synthetic hormones, pesticides and plastics. They do not react in our body the same way as natural estrogens, and can be difficult to eliminate from the body. Xenoestrogens have been associated with disrupted reproductive processes.

But it is not just xenoestrogens that can cause problems. Estrogen has long been considered a risk factor for a variety of women's problems, especially of the breast. In fact, the risk of breast complications has been shown to increase with the number of premenopausal years, when estrogen levels are highest. Research has shown that natural estrogens can also be classified as "good" or "bad". For example, experimental and clinical evidence has shown that 16-hydroxylated estrogen metabolites have stronger estrogen activity and are associated with breast disease, while 2-hydroxylated estrogen metabolites are weaker and are not associated with increased risk.

Fortunately, there are natural solutions available that can help tip the balance towards the "good" estrogens, and to help detoxify and eliminate "bad" estrogens and xenoestrogens. The ingredients in Estro Detox work together to promote a healthy estrogen balance and to promote the detoxification of harmful substances, thereby helping to reduce the risk of women's issues.

D-Glucarate

D-glucarate is a naturally occurring compound that is produced by the body in small amounts and is also found in many fruits and vegetables. D-glucarate plays a very important role in the detoxification of toxins and carcinogens. One very important detoxification pathway in the body is the glucuronidation pathway. Through glucuronidation toxic substances, environmental carcinogens and even excess levels of estrogen are neutralized, and then eliminated from the body.

Unfortunately, this important detoxification process can be disrupted by the enzyme beta-glucuronidase, which acts to reactivate the neutralized toxins. Elevated levels of this enzyme have been associated with an increased incidence of breast, prostate and colon unhealthy cell growth. This is where D-glucarate comes in. The primary action of D-glucarate is to inhibit the enzyme beta-glucuronidase, thereby promoting detoxification.

Research has shown that D-glucarate can promote health breast cell development in mice by as much as 70%. Calcium-D-glucarate's inhibition of beta-glucuronidase also allows the body to excrete estrogen before it is reabsorbed by the body. In this way D-glucarate can help to encourage healthy estrogen metabolism, and prevent elevated estrogen levels. D-glucarate has been shown to lower serum estrogen levels in rats by 23%. Preliminary studies in humans show that D-Glucarate supplements are safe, and have the same effects on beta-glucuronidase in people that they do in animals. Studies on D-glucarate supplements in women at risk for breast problems are underway, and it has been suggested that D-glucarate may provide a safe, effective and side-effect free alternative to the drug tamoxifen.

3,3'-Diindolymethane (DIM)

DIM is a naturally occurring phytonutrient found in cruciferous vegetables like broccoli. DIM has been shown to promote the formation of 2-hydroxylated estrogen metabolites instead of 16-hydroxylated estrogen metabolites. This means that DIM helps to push the balance of estrogen in the body towards the production of "good" estrogens and reduces the production of "bad" estrogens. In cell culture studies DIM has powerful healthy cell growth promotion, and has been shown to help breast and cervical immune health growth in vitro. It has also been shown to block the activation of genes that promote unwanted cell growth while activating genes that help promote good immune response.

Human studies also show promising results. DIM is currently used to treat Recurring Respiratory Papillomatosis caused by the Human Papilloma Virus and is in Phase III clinical trials for Cervical Dysplasia. Cervical Dysplasia is a precancerous condition also caused by the Human Papilloma Virus, and is highly correlated to the development of cervical issues. Preliminary open-label testing has shown that treatment with DIM successfully resolved moderate to severe cervical dysplasia.

choline

Choline is a member of the B Vitamin family and is a water-soluble essential nutrient for the human body. It plays a number of important roles including maintaining the structure of cell membranes and improving cell signaling. It is also one of the few substances that can cross the blood-brain barrier to produce chemical messengers in the brain called neurotransmitters.

The most important of these choline-based neurotransmitters is acetylcholine, the molecule responsible for memory. It is commonly recommended by natural health care practitioners for a variety of different therapeutic applications, including: Fatty Liver, Cardiovascular Health, Depression, poor concentration, and neurological diseases such as Multiple Sclerosis, Tardive Dyskinesia, and Parkinson's disease.

Hops Extract 8-prenylnarigenin

8-prenylnaringenin (8PN) is a component found in hops that is a potent phytoestrogen, or plant estrogen. It has been shown to be of equal or greater potency as soy-derived phytoestrogens like genistein. In vitro 8PN has been shown to inhibit breast unwanted cell proliferation by interfering with certain pathways mediated by the estrogen receptor. 8PN has also been shown to prevent angiogensis (the formation of new blood vessels to feed tumors) both in test tube and animal studies.

Furthermore, 8PN has benefits for women with menopause. One double blind randomized cross over study (specifically designed to take into account the high degree of "placebo" effect common with menopausal studies) showed that 8PN reduced hot flashes, night sweats and other menopausal symptoms significantly. In animal studies, it has also been shown to help reduce atherosclerosis and reduce cholesterol levels. It has been proposed that 8PN may help to prevent the incidence of cardiovascular disease associated with low estrogen levels. Lifenol's hops extract is standardized to contain an effective level of 8PN, and has been studied in numerous clinical trials.

CAUTIONS:
Do not take if pregnant or breastfeeding. Consult a health care practitioner if you are attempting to conceive, taking hormone replacement therapy, birth control pills or other medications, if you have or are predisposed to immune issues or a liver disorder, if you develop liver-related symptoms (e.g. abdominal pain, jaundice), depression, and/or related diseases, if symptoms persist or worsen, or for use beyond three weeks. Consumption of hops with alcohol, other medications, and/or natural health products with sedative properties is not recommended. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle, or are involved in activities requiring mental alertness. Discontinue use and consult a healthcare practitioner if you experience joint pain or hot flashes, or if you experience irregular menstruation.

If you have symptoms of low estrogen (such as joint pain, mood changes, change in libido, hot flashes, night sweats, vaginal dryness or irregular menstruation); consul a health care practitioner. Consult a health care practitioner prior to use if you are taking blood thinners or natural health products. May temporarily alter urine color, consult a health care practitioner if urine does not normalize upon discontinued use. If sleeplessness (insomnia) occurs for more than 4 weeks, if you develop liver related symptoms (e.g yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen, discontinue use and consult a health care practitioner. To exclude the diagnosis of a serious hormonal imbalance, consult a health practitioner prior use.